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This transgene consists of an optimized reverse tetracycline transactivator under the control of the mouse alpha myosin heavy chain. rtTA is optimized by changing 5 amino acids (S12G, E19G, A56P, D148E, and H179R referred as M2) in the synthesized (S2) construct and linking it to 3 repeats of a 12-amino-acid sequence, FFF, which is the minimum activator domain of VP16. The transgene is expressed in the heart only when doxycycline is present. (J:125131)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
