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The light chain intronic enhancer Ekappa, located between Igkj and Igkc gene segment clusters, was replaced with 0.8 kb XbaI fragment of the Igh locus that spans the entire heavy chain intronic enchancer element (Emu or Rr150) and flanking matrix attachment regions. A floxed neomycin selection cassette was included downstream. The neomycin selection cassette was removed by transient Cre recombinase expression. (J:124407)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
