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A targeting vector was designed to replace exons 4-7 with a neomycin resistance cassette and a thymidine kinase (TK) gene. Western blotting revealed the complete absence of protein in homozygous mutant testes. Immunohistochemical analysis and immunofluorescence confirmed the absence of detectable protein in homozygous mutant sperm. (J:101977, J:219150)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
