Log In|Sign Up
EN
A targeting vector was designed to replace exons 2-5 and part of exon 6 with a neomycin resistance cassette. Analysis of mutant MEFs determined that a transcript is produced, and sequencing showed it resulted from exon 1 being spliced to exon 7, with a continuous open reading frame. A protein lacking the cysteine-rich domain (exon 2), the FNII domain (exon 3) and the first CTLD (exons 4-6) was expressed. (J:124909)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
