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A 5.2 kb fragment encoding H2-Ead was ligated 3' of the Igk enhancer/promoter sequences (Igk-Eik), where the enhancer is a 0.9 kb fragment from the J-C intron. The construct was microinjected into (C57BL/6 x SJL)F2 oocytes. Transgene expression was observed in B-cell areas of the spleen, but density of I-E on spleen and lymph node B-cells was low relative to endogenous I-A or Ig. (J:124907)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
