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This transgene contains the chicken beta-actin promoter and the cytomegalovirus immediate-early (CMV-IE) enhancer driving expression of a fusion gene consisting of the enhanced green fluorescent protein coding sequence joined to the full-length open reading frame of the human TSC22 domain family, member 1 gene. A human salivary gland tumor cell line stably transfected with the same construct minus the beta-actin promoter exhibits fluorescence in the cytoplasm, but not in the nucleus; when cells of this line are induced to undergo apoptosis by treatment with 5-fluorouracil, the fluorescent fusion protein is translocated to the nucleus. (J:104881, J:124640, J:124641)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
