Tg(CMV-IgkvaD11)BCat

The transgenic construct included a recombined Igk variable region encoding the light chain of the rat anti-nerve growth factor monoclonal antibody, alphaD11. The human immunoglobulin kappa constant region (IGKC) was included downstream to enable the detection of the transgenic antibodies against murine immunoglobulins. The early region promoter (-601 to -16) of human CMV reportedly drove expression of the transgene in non-neuronal tissures as well as in neuronal tissues including the cortex, hippocampus, thalamus, spinal cord, retina, olfactory bulb, and cerebellum. Line B shows higher light chain transgene expression than line A. (J:79946)