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A screen of sera from mice of 73 strains for deficiencies in complement-mediated lysis of antibody-primed rabbit or sheep erythrocytes identified two strains, of 8 derived from the wild hybrid species M. m. molossinus, lacking lytic activity. Their hemolytic activity was restored by addition of partially purified human complement factor 8 or of human serum depleted of C8alpha and C8gamma. The gene responsible in strain MSM/Ms was mapped to the region of the mouse genome sharing synteny with the chromosomal location of human C8B. Combined sera from the two deficient strains also lacked hemolytic activity. (J:11000)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
