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Murine App cDNA containing R609D and K612E mutations was inserted downstream of the human APP gene promoter with a beta-globin intron interspersed. The construct was microinjected into 1.5-day-old pre-nuclear embryos from FVB females. Transgene expression in the brain was verified by RT-PCR. Expression was low compared to endogenous App levels in the mouse brain. (J:32213)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
