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A targeting vector replaced exons 2, 3 and part of exon 4, sequences that encode the DNA binding domain, with a floxed neomycin resistance cassette. Expression of a cre transgene carried by the parental ES cells removed the floxed neo cassette upon passage through the male germline. Northern blot confirmed absence of transcript in mutant mice. (J:123628)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
