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A targeting vector containing a floxed neo cassette was inserted by homologous recombination in ES cells and subsequently removed by Cre mediated recombination upon tranmission from male chimeric mice, resulting in the deletion of the homeodomain. Targeting took place in ES cells that contain the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells. Absence of endogenous transcript was confirmed by RT-PCR. (J:123638)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
