LoxP sites were introduced upstream of exon 2 and downstream of exon 4, flanking a portion of the oligomerization domain and residues in the catalytic domain required for enzymatic activity. A FRT-flanked neo was removed from the locus via Flp mediated recombination. (J:123173)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count