Log In|Sign Up
EN
The construct contains a 1.35 kb porcine transforming growth factor beta 1 (TGFB1) cDNA inserted into the first exon of the mouse glial fibrillary acidic protein (Gfap) gene, making a fusion gene The TGFB1 cDNA has been mutated to encode serines at positions 223 and 225, instead of cysteines, to ensure secretion of a bioactive peptide. The linear construct was microinjected into (BALB/c x SJL)F2 one-cell stage embryos. Line 64 founder mice expressed low levels of TGFB1 mRNA in the brain. Line 115 was also generated and shows very similar properties. (J:27781)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
