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cDNA encoding the human wild-type amyloid precursor protein (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum. (J:53800)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
