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A cDNA encoding the human APOE isoform 4 was cloned into a vector downstream of the rat glial fibrillary acid protein (Gfap) promoter and regulatory elements and upstream of the human beta-globin splice and polyadenylation sites. The linearized construct was injected into the male pronuclei of B6D2F1 zygotes. (J:100970)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
