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The transgene contains the human beta actin promoter upstream of a chimeric gene encoding an enhanced tetracycline regulated repressor protein (tTS) that comprises the C-terminal portion of the E. coli Tn10 tetracycline repressor (TetR) protein, the 6-amino acid SV40 large T-antigen nuclear localization signal and the N-terminal 121 amino acids of the human ZNF10 (KOX1) zinc finger protein, which contains the KRAB repressor domain, followed by an SV40 polyadenylation signal. The expression construct is flanked by chicken beta-globin insulators. (J:82970)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
