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The transgene comprises 8.5 kb of upstream flanking DNA and 85 bp of the 5', noncoding exon of the mouse calcium/calmodulin-dependent protein kinase II alpha gene, an artificial intron and splice signal, the coding sequence for the reverse tetracycline-regulated transactivator (rtTA) protein and an SV40 polyadenylation signal. Maximal doxycycline induction of mice bearing both this transgene and a lacZ reporter transgene under control of the tetracycline operator (tetO) demonstrated expression in the CA1 and CA2 regions, but only minimal expression in the CA3 region, of the hippocampus; in the dentate gyrus; in both superficial layers and a deep layer of the cortex; and in the septum and striatum. (J:123059)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
