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Cre-mediated recombination in the germline resulted in the loss of exon 3, which encodes the second zinc finger of the DNA-binding domain. This deletion has been designed to retain the normal reading frame so that the mutant AR can bind ligand but is unable to bind DNA and regulate target gene transcription. (J:123057)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
