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The tranthyretin promoter was fused to the human KLF6 cDNA to induce hepatoyte-specific overexpresson that is two- to three-fold above normal levels. Expression is localized to hepatocytes with variable expression in the choroid plexus of the brain at high transgene copy number. In addition to transgenic line 1, lines 4 and 9 were also made. (J:122903)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
