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The Dvl2 promoter drives the expression of Dvl2 with EGFP fused downstream of the 15th exon with a LoxP site inserted 3' of Acadvl, and a point mutation introduced at the codon 446. This mutation is predicted to alter lysine 446 to methionine in the encoded protein. The point mutation is identical to a varaint identified in Drosophila that abolishes planar cell polarity function. (J:108512)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
