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Mouse strain C3H/DiSnA carries a C to T nucleotide substitution at coding nucleotide 1303 (c.1303C>T) changing arginine codon 435 into a premature stop codon in exon 7. Liver mRNA expression is reduced 10-fold in this strain and serum ferrioxidase activity is absent. This allele confers increased liver iron content compared to inbred strain C57BL/10ScSnA and recombinant congenic strain HcB-2/Dem. (J:122133)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
