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A targeting vector was designed to place a neomycin cassette in intron 6, and delete amino acids 322-332 and 425-431 of exon 7. Protein levels are similar to wild-type as shown by immunoprecipitation, but the level of protein binding to Rac GTPase-activating protein (WRP) is reduced by 50%. (J:117303)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
