A targeting vector was designed to insert the W3587A/L3591AD/F3603A mutations into exon 75. A floxed neo was subsequently removed via cre mediated recombination. (J:122033)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count