The high affinity variant of the reverse tetracycline controlled transactivator, together with an IRES, was inserted into the 3' UTR of the locus. The frt-flanked neo that was included in the vector downstream of the rtTa was removed by Flp recombinase expression. (J:119721)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count