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This transgene consists of the coding region of the mouse Eda-A1 isoform inserted between TRE/PminCMV promoter and SV40 poly A region. The tetracycline-controlled transactivator (tTA) binds to TRE and activates transcription. Expression of Eda is repressed by the addition of doxycycline and is expressed in doxycycline absence. The receptor for the Eda-A1 isoform is Edar. (J:86628)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
