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A translational stop codon was introduced at codon 73 in exon 3 in the targeting vector. The vector also contains both a tACE-Cre and neoR module. Recombination in ES cells introduced the stop codon into the Ncf4 sequence. When chimeras were bred, tACE promoter activity in testes promoted Cre/loxP-mediated deletion of the cassette, leaving 59 bp of foreign DNA. No Ncf4 protein can be detected by antibodies in homozygous mice. (J:121820)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
