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A transgenic construct was designed with a FLAG-epitope sequence tag at the amino terminus of a truncated mouse CREB-binding protein sequence (called CBPdelta1; lacking the coding sequence for amino acids 1084-2441), all flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end. This FLAG-CBPD1 sequence was then placed downstream of 8.5 kb of the mouse CaMKIIalpha promoter. The resulting 13 kb "CaMKIIalpha-FLAG-CBPdelta1" transgene was microinjected into the pronuclei of B6SJLF1 zygotes. Expression of the truncated product is restricted to the post-natal hippocampus, striatum, amygdala, and cortex. (J:121812)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
