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The transgene contains a mouse anti-Ctla4Ig/Cd80 fusion cDNA from which a cell surface bound form of the CD152 antigen (Ctla4Ig) is expressed under control of the IgM heavy chain promoter and enhancer, which directs expression to B cells. To prevent reverse signaling in the transgene expressing cell, the construct was created using a DNA fragment expressing the transmembrane domain from Cd80(B7-1), which lacks the C-terminal, intra-cytoplasmic tail. (J:113109)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
