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A loxP-flanked kanamycin/neomycin drug resistance cassette and a GFP/IRES/PLAP fragment were targeted to replace the first exon of the mouse Crx gene in a BAC clone by ET-cloning. Cre was activated in the EL250 bacterial host strain with arabinose to remove the floxed kanamycin/neomycin segment, and the resultant BAC was digested with NotI to generate a transgenic fragment. (J:120988)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
