LoxP sites were inserted to flank exon 2, as well as tk and neo selection markers. The selection markers were removed by transient transfection with Cre recombinase, leaving a floxed exon 2. (J:119977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count