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A targeting vector was designed to delete the bHLHO domain, which is encoded by exons 2 and 3. A tau-lacZ fusion cassette was inserted in frame with the 12th codon in exon 2, followed by a floxed neomycin resistance cassette. The neo was subsequently removed by cre-mediated recombination. Absence of transcript was confirmed by RT-PCR. Expression of the mutant protein was confirmed by in situ hybridization. (J:119562)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
