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A vector including an IRES-LacZ and a floxed PGK-neo cassette was unexpectedly inserted at the 3' end of the gene resulting in minimal disruption of the coding sequence. Correct expression of the reporter relative to the endogenous protein was confirmed by beta-glactosidase assay and immunostaining brain sections with antibodies for Lhx6 and beta-galactosidase. QRT-PCR confirmed reduced transcript expression. This allele is hypomorphic. (J:119476, J:198547)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
