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A neo cassette with a 3' loxP site followed by an alkaline phosphatase gene with a 3' loxP site was inserted into exon 3. Transient cre expression was used to knockin a transgene composed of 1.4kb of the promoter of Penk1, 600bp of the 5' UTR and first intron of Penk1 fused to a LacZ cassette and the 3'UTR of Penk1 between the alkaline phosphatase gene and the second loxP site. RT-PCR confirmed transgene expression of LacZ mRNA in brain, heart and liver tissue. (J:81778)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
