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The transgene was created by combining the Igh-6 enhancer with a minimal SV40 promoter to drive the expression of a cre-ERT mutant fusion protein. The fusion protein consisted of cre recombinase fused to the estrogen binding domain of the human estrogen receptor mutated at amino acid 521 (G521R). Expression in ~ 75% of peripheral blood B lymphocytes was confirmed with an anti-cre antibody. (J:69333)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
