DNA sequence encoding a fusion protein comprised of cre recombinase and a mutated ligand binding domain of Esr1 (ERT2) was inserted at the endogenous locus via homologous recombination. Activation of cre recombinase activity is dependent on the administration of 4-OH-tamoxifen. (J:104582)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count