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The sequence of codon 58 was altered from CGC to GCC resulting in an arginine to alanine amino acid substitution (p.R58A) that disrupts PtdIns3P binding. A self-excising floxed tACE-Cre expression module and neo cassette was inserted into intron 3, and was removed by cre-mediated excision specifically in the testis during breeding of the chimeras. (J:119217)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
