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An FRT-flanked neomycin resistance cassette was inserted in reverse orientation just downstream of the DQ52 region in a plasmid containing DQ52 (Igh-D). A heavy chain variable-diversity-joining (VDJ) segment of HyHEL10 sequences were placed downstream of the neomycin cassette, replacing the Igh-J (Jh1-4) locus. A loxP site was added to a downstream SpeI restriction site, between the Igh-6 (IgM/mu) enhancer and the Igh-6 switch region, for use in future gene targeting. The immunoglobulin heavy chain locus is of the Igha allotype. (J:118931)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
