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A linearized bacterial artificial chromosome (BAC) containing the 54-kb human telomerase reverse transcriptase gene, including at least 11 kb of upstream sequence, all of the exons and introns, and 1.2 kb of downstream sequence, was microinjected into C57BL/6 oocytes. Transcript expression patterns of the human gene in most organs of transgenic mice are generally characteristic of TERT expression in humans, rather than of the endogenous mouse gene; the exception is that human TERT, which is not expressed in human brain, is like the mouse enzyme expressed in mouse brain. (J:117922)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
