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A human genomic YAC clone (35EB2) that encompasses the caspase 3 gene was used to create the transgene. This construct contains all seven exons of the gene and the 3' untranslated region (UTR) of human caspase 3, as well as 80 kb of upstream and 50 kb of downstream regulatory sequences. Expression of the line F18 transgene is essentially identical to that of the murine protein with highest levels being detected in the spleen, thymus, liver, kidney and brain. An additional line, F57, was also created. (J:101696)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
