Crossing Flnatm1.1Caw females with males expressing a beta-actin cre transgene results in deletion of exons 3-7. Cre recombination in floxed ES cells to produce null mutants is inefficient because the cells are male-derived and deletion of the x-linked gene results in embryonic lethality. (J:118252)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
Intragenic deletion
--
1
22
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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