Crossing Flnatm1.1Caw females with males expressing a beta-actin cre transgene results in deletion of exons 3-7. Cre recombination in floxed ES cells to produce null mutants is inefficient because the cells are male-derived and deletion of the x-linked gene results in embryonic lethality. (J:118252)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count