Threonine codons 76 (ACC) and 86 (ACT) were changed to alanine (GCC, GCT) (p.T76A, p.T86A). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 6 was removed through subsequent Cre-mediated recombination. (J:118244)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae-Tg(Prm-cre)70Og
Targeted
Nucleotide substitutions
--
1
65
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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