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Two co-injected transgene constructs both employ the regulatory sequences of the mouse procollagen, type XI, alpha 2 (Col11a2) gene, in a DNA fragment excompassing nucleotides -742 through +380 (relative to the transcription start site), to direct expression to developing chondrocytes. One construct contains a full-length, 2.2-kb cDNA encoding the wild-type mouse exostoses (multiple) 2 protein, followed by the SV40 splice donor/acceptor and polyadenylation signal. In the second construct, the mouse cDNA is replaced by the E. coli beta-galactosidase (lacZ) coding sequence. (J:48125, J:75965)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
