A targeting vector was designed to insert a modified exon 4 such that it was fused to exon 3 as well as a floxed neo cassette that was inserted into exon 4. The neo cassette was then removed by mating with Tg(ACTB-cre)2Mrt mice. (J:114533)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count