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A replacement vector was used to disrupt exons 1 and 2 of the Apoc1 gene by replacing them with a 2 kb hygromycin B-resistance gene. The vector was transfected into a heterozygous Apoe-deficient E14 ES cell line. Mice produced from the doubly targeted ES cells disrupted alleles of both Apoe and Apoc1. (J:22858, J:28261)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
