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The transgene is a 6.2 kb human genomic DNA fragment containing the entire lecithin-cholesterol acyltransferase (LCAT) gene plus 851 bp of 5' and 1,134 bp of 3' flanking sequence. Based on Southern blot analysis, hemizygous mice of this founder line harbor 15 transgene copies. The plasma level of LCAT in mice with this transgene is 11-fold that of endogenous LCAT in non-transgenic mice. Northern blot analysis of various tissues from transgenic mice demonstrates expression of LCAT primarily in the liver, with much weaker expression in testis, brain, heart and lung. (J:118356)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
