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Embryonic stem cells were infected with the retroviral gene trap vector ROSABetageo, which contains a splice acceptor site joined to the Betageo (lacZ-neomycin resistance) fusion gene. The trapped gene was inactivated by integration of the vector. Tissue-specific beta-galactosidase activity has been demonstrated by X-gal staining in neural tissues of developing embryos by embryonic day 8.5 (E8.5) and in gonocytes of E15 female embryos. Expression is also observed in the male gonad by postnatal day 8; it is restricted to pachytene spermatocytes in the adult male. (J:82809)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
