In the first step of a two step process, exons 3-5 were replaced with an Hprt minigene. In the second step, the Hprt1 marker was replaced with the Ercc1 exons 3-5 region flanked by loxP sites. (J:115849)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count