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The protein product of this transgene, whose transcription is under control of the dendritic cell- (DC-) specific mouse integrin alpha X (Itgax/Cdc11c) promoter, is a fusion of Cre recombinase and a mutant hormone-binding domain from human estrogen receptor 1 (ESR1). Following TAM treatment of mice bearing both this transgene and an EGFP-expressing Cre recombinase reporter transgene, green fluorescence was observed in 4-8% of CD11c+ cells in the spleen, lymph nodes, and thymus, but in no CD11c- cells. Staining of Cdc11c+ splenocytes from these mice with CD8alpha-APC/CD-PE 40 hours after TAM administration revealed fluorescence of all major classes of DC. (J:114742)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
