Tg(Myh6-TNNI3*G203S)1Chs

This transgene consists of human TNNI3, with an amino acid substitution of a glycine by serine at codon 203 that causes familial hypertrophic cardiomyopathy in humans, under the control of the cardiac specific alpha-myosin heavy chain promoter. This line expresses the highest amount of mutant protein and represents relative proportions of mutant protein of 83%. (J:114537)