Sh3pxd2b^nee

A spontaneous mutation removes the A nucleotide at position 1220 (c.1220delA) in tyrosine codon 407. This mutation leads to a frame shift altering 37 amino acid before resulting in a premature stop codon and truncation of the protein product to 443 amino acids compared to the full-length 908 amino acids. The truncated protein lacks the fourth SH3 domain. (J:153369)